Principal Scientist, Medicinal Chemistry
Join Iambic Therapeutics as a Principal Scientist in Medicinal Chemistry to lead drug discovery efforts in a collaborative environment.
Posted by employer 5 months ago
First seen on Joblaze 1 week ago
Last verified on the company career page 9 hours ago
Skills & Technologies
AI in the day-to-day
Work closely with AI/ML teams to develop and implement relevant predictive models to aid in the design of new molecules.
Requirements
- Experience
- 8–15 years
- Education
- PhD
Not disclosed in this posting: compensation, visa sponsorship.
Benefits
Joblaze summary
In this role, the Principal Scientist in Medicinal Chemistry will focus on developing and optimizing lead molecules for drug discovery, employing advanced synthetic methods and innovative techniques. The position requires expertise in synthetic organic chemistry, with a strong background in small molecule drug discovery and experience in lead optimization for various properties. This role is ideal for a seasoned professional with a collaborative mindset, capable of integrating multiple research disciplines and effectively communicating with diverse teams. Iambic Therapeutics, a clinical-stage company, emphasizes a culture of innovation and teamwork, leveraging AI-driven technologies to advan
Joblaze insights
- Listed 10 days ago on Joblaze — tracked directly from Iambic Therapeutics's career page.
- Iambic Therapeutics has 24 other open roles including Director, Compensation, Benefits and HR Systems, Research Scientist I/II, Purification Sciences, Associate Medical Director/Medical Director.
- 5189 active AI/ML roles on Joblaze right now.
- 11 active computational chemistry roles on Joblaze right now.
- 5 active Medicinal Chemistry roles on Joblaze right now.
- Typical AI/ML salary we track runs $140,000–$230,000 (median $180,000, across 2254 roles). See AI/ML salary trends
Quick facts
- Is the Principal Scientist, Medicinal Chemistry role remote?
- No — this is an on-site role in San Diego HQ.
- How much experience is required?
- 8–15 years of relevant experience for this Principal Scientist, Medicinal Chemistry role.
- Where is the role based?
- Iambic Therapeutics is hiring for this position in San Diego HQ.
- What's the tech stack?
- Joblaze extracted these technologies from the posting: AI/ML, Medicinal Chemistry, Synthetic Organic Chemistry, computational chemistry.
- What seniority level is this role?
- Iambic Therapeutics targets principal-level candidates for this position.
- Is this full-time or contract?
- Full-time for this Principal Scientist, Medicinal Chemistry role at Iambic Therapeutics.
From the original posting
JOB SUMMARY
We seek an experienced and creative medicinal chemist with a proven track record of success in drug discovery. Candidates should be motivated to work in an intensely collaborative, multidisciplinary, team-based setting. The ideal candidate will be passionate about solving medicinal chemistry challenges, as well as proactively interfacing with diverse teams working on automated experimentation, AI-driven molecular generation, property predictions, and bioassay data generation.
This position is on-site at our San Diego Headquarters.
KEY RESPONSIBILITIES
Devise strategies to identify lead molecules and optimize them for potency, selectivity, and ADME properties using multivariant SAR analysis and hypothesis driven design principles.
Execute on high quality ideas by employing a broad range of modern organic chemistry transformations, synthetic methods, creative use of parallel experimentations and implementing innovative techniques.
Work closely with molecular and cellular biology, pharmacology, computational chemistry, ADME, and other key functions
Influence the prospective use of computational methods and leverage automated synthesis and high-throughput experimentation capabilities
Work closely with AI/ML teams to develop and implement relevant predictive models to aid in the design of new molecules
Communicate project updates clearly and effectively to the broader team and key stakeholders
Work as a member of the Chemistry research group and foster a culture of scientific excellence, innovation, and teamwork
QUALIFICATIONS
BS, MS, or PhD in chemistry with a focus on synthetic organic chemistry
Experience in small molecule drug discovery in a biotechnology or pharmaceutical setting and a B.S. with 15+ years’ experience, M.S. with 12+ years’ experience or Ph.D. with 8+ years’ experience.
Proven track record of success in advancing programs from leads to advanced candidates.
Extensive experience in lead compound optimization for potency, selectivity, ADME and PK.
Expert in modern synthetic organic chemistry approaches and principles demonstrated through publications in journals and patents
Practical experience and working knowledge of target protein degradation and associated modalities (molecular glues, PROTACS)
Ability to integrate multiple R&D disciplines into a successful strategic project plan
Experience working with computational chemists as part of project team in design of drug targets is required
Strong interpersonal, communication, time management, and leadership skills
Creative problem solving and management of relationships with several stakeholders within and beyond the company
ABOUT IAMBIC THERAPEUTICS
Iambic is a clinical-stage life-science and technology company developing novel medicines using its AI-driven discovery and development platform. Based in San Diego and founded in 2020, Iambic has assembled a world-class team that unites pioneering AI experts and experienced drug hunters. The Iambic platform has demonstrated delivery of new drug candidates to human clinical trials with unprecedented speed and across multiple target classes and mechanisms of action. Iambic is advancing a pipeline of potential best-in-class and first-in-class clinical assets, both internally and in partnership, to address urgent unmet patient need. Learn more about the Iambic team, platform, pipeline, and partnerships at iambic.ai.
MISSION & CORE VALUES
Our mission is to deliver better medicines through innovations in AI-based discovery technologies. The culture and work at Iambic Therapeutics are profoundly strengthened by the diversity of our people and our differences in background, culture, national origin, religion, sexual orientation, and life experiences. We are committed to building an inclusive environment where a diverse group of talented humans work together to discover therapeutics and create technologies.
PAY AND BENEFITS
We offer industry leading competitive pay, company paid healthcare, flexible spending accounts, voluntary life insurance, 401K matching, and uncapped vacation to our team. We are in a brand-new state-of-the art facility in beautiful San Diego with an onsite gym, dining, and easy access to great places to live and play.