How much experience is required?

At least 10 years of relevant experience for this Director, DMPK role.

What seniority level is this role?

Alpha-9 Oncology targets director candidates for this position.

Is this full-time or contract?

Full-time for this Director, DMPK role at Alpha-9 Oncology.

Director, DMPK at Alpha-9 Oncology

Joblaze summary

In the role of Director of DMPK at Alpha-9 Oncology, the individual will lead the development and execution of pharmacometrics and DMPK strategies to optimize radioligand therapies throughout their clinical journey. Key skills include expertise in pharmacokinetics, biodistribution, and quantitative modeling, particularly within the context of radiopharmaceuticals. This position is suited for a seasoned professional with over a decade of relevant experience, capable of guiding cross-functional teams and translating complex data into actionable insights.

Joblaze insights

Listed today on Joblaze — tracked directly from Alpha-9 Oncology's career page.
Alpha-9 Oncology has 3 other open roles including Join the Alpha-9 Talent Network, Associate Director, Regulatory Strategy, Clinical Trial Manager.

Quick facts

How much experience is required?: At least 10 years of relevant experience for this Director, DMPK role.
What seniority level is this role?: Alpha-9 Oncology targets director candidates for this position.
Is this full-time or contract?: Full-time for this Director, DMPK role at Alpha-9 Oncology.

From the original posting

Your Impact

At Alpha-9 Oncology, we are working to advance a differentiated pipeline of radiopharmaceutical therapies for patients with cancer. As we continue to advance our programs, deep understanding of the pharmacokinetics, biodistribution, and pharmacology of radioligand therapies will be critical to optimizing our pipeline and advancing programs toward and through the clinic. As the Director, you will play a central role in developing and executing DMPK and pharmacometrics strategies across our pipeline. You will work at the intersection of DMPK, pharmacometrics, radiopharmaceutical science, and translational development to generate the quantitative insights needed to guide candidate selection, dose and regimen optimization, clinical development, and regulatory strategy.

This is a highly visible, hands-on scientific leadership role within a lean organization. Working closely with the CMO and leaders across R&D, Translational Sciences, Clinical Development, CMC, Regulatory, and external partners, you will help define how quantitative pharmacology and DMPK are applied to the unique challenges of radioligand therapy development.

The right person will bring deep expertise in DMPK and pharmacometrics within RLT, a strong understanding of radiopharmaceutical development, and the scientific judgment to translate complex PK, biodistribution, imaging, and dosimetry data into clear development decisions.

How You’ll Contribute

Lead pharmacometrics and quantitative pharmacology strategy across Alpha-9's RLT pipeline from preclinical development through clinical development.
Develop RLT-specific PK/PD, population PK, PBPK, and mechanistic modeling strategies to support candidate selection, translation, and human dose prediction.
Lead quantitative approaches to characterize RLT pharmacokinetics, biodistribution, tissue exposure, target engagement, and exposure-response relationships.
Develop and integrate quantitative PET/SPECT imaging and dosimetry strategies to support absorbed dose assessment, dose selection, and clinical decision-making.
Lead dose-finding, dose and regimen optimization, and quantitative development strategies across FIH, dose escalation, expansion, and later-stage RLT studies.
Integrate PK, pharmacology, imaging, dosimetry, efficacy, and safety data to inform program strategy, development decisions, and portfolio priorities.
Provide pharmacometrics and quantitative pharmacology leadership for regulatory submissions and Health Authority interactions supporting RLT programs.
Lead external quantitative pharmacology, DMPK, imaging, and dosimetry activities with CROs, consultants, and academic collaborators.
Build Alpha-9's RLT quantitative sciences capabilities through scientific leadership, mentoring, and development of innovative and fit-for-purpose approaches.

The Skills You Bring

Ph.D. in Pharmacokinetics, Pharmaceutics, Pharmaceutical Sciences, Pharmacology, Chemical Engineering, or a related scientific discipline.
10+ years of experience in pharmacometrics, quantitative pharmacology, DMPK, clinical pharmacology, or a related discipline within biotechnology or pharmaceutical organizations.
Significant, hands-on experience applying pharmacometrics, quantitative pharmacology, or DMPK to radioligand therapy or targeted radiopharmaceutical development is required.
Deep expertise in PK/PD, population PK, PBPK, mechanistic modeling, exposure-response, and dose optimization.
Demonstrated experience integrating PK, biodistribution, quantitative imaging, and dosimetry into RLT development strategies.
Experience supporting RLT programs across multiple stages of development, including FIH, dose escalation, expansion, and later-stage studies.
Experience in contributing to RLT regulatory submissions and Health Authority interactions is required.
Strong scientific understanding of the relationship between RLT exposure, target engagement, biodistribution, absorbed radiation dose, efficacy, and safety.
Demonstrated ability to lead cross-functional scientific teams and external partners and translate complex quantitative analyses into clear development recommendations.
Strong experience with population PK, PK/PD, PBPK, mechanistic modeling, or related pharmacometrics approaches.
Experience supporting clinical-stage programs, regulatory submissions, and Health Authority interactions.
Demonstrated ability to lead cross-functional teams, external partners, and complex scientific initiatives.

Company Summary

Alpha-9 Oncology is a clinical-stage biotechnology company pioneering radiopharmaceutical innovation for solid tumors. Our proprietary scaffolds, composed of optimized binders, linkers, chelators, and radioisotopes, enable targeted radiation delivery to cancer cells, minimizing harm to surrounding healthy tissue. Focusing on innovative targeting moieties, we develop molecules tailored for precise tumor targeting.

Our comprehensive platform integrates imaging and therapeutic studies to ensure effective radiation delivery and improved patient outcomes. With a robust pipeline entering clinical trials and strong support from leading healthcare investors, Alpha-9 is positioned for rapid growth and advancement in cancer therapy.

More about Alpha-9 Oncology

Alpha-9 Oncology is committed to fostering a diverse and inclusive workplace and is proud to be an Equal Opportunity Employer. We provide employment opportunities to all qualified applicants without regard to race, ethnicity, religion, age, sex, gender identity or expression, sexual orientation, disability, marital status, family status, national origin, or any other characteristic protected by applicable federal, provincial, or local laws where we operate.

We are dedicated to providing reasonable accommodations to qualified applicants and employees to ensure that everyone can perform their essential job functions in an inclusive environment. For inquiries regarding accommodations in the hiring process or for current employees, please contact a member from our Talent Acquisition team.

Director, DMPK

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