Scientist II, High Throughput Biology

About the Role

We are seeking a highly motivated Scientist II to join our dynamic team at Xaira Therapeutics. In this role, you will spearhead the design and execution of cutting-edge experiments aimed at accelerating our drug discovery and development efforts by applying functional genomics and synthetic biology approaches, developing high-throughput screens and driving new technology initiatives. The successful candidate should possess strong technical expertise & laboratory skills, have excellent written and oral communication skills, work productively in a collaborative cross-functional team environment, and keep current with the field of expertise, including literature and technology development.

Key Responsibilities

• Design, implement, and optimize biochemical, molecular and cell-based assays to support high throughput screening platform development.
• Scale high-throughput screening strategies for binder discovery in mammalian systems.
• Evaluate and pilot emerging technologies and experimental workflows to enhance discovery capabilities.
• Develop and optimize automated workflows, ensuring data quality, reproducibility, and process efficiency
• Partner with drug discovery, computational biology, and AI-based protein design teams to analyze, interpret, and share insights from screening data.
• Independently manage multiple projects, ensuring timely delivery of high-quality data and adherence to team goals.
• Maintain accurate records of experiments, protocols, and findings, and contribute to internal and external scientific presentations.

Qualifications

• Ph.D. in Immunology, Molecular Biology, Cell Biology, Biochemistry, Functional Genomics, or related field, with 2-4 years of postdoctoral or industry experience.
  • (Recent PhD graduates or candidates with with fewer years of experience are also encouraged to apply and job level can be adjusted as appropriate)
• Proficiency with molecular biology techniques, complex library construction, flow cytometry and cell line engineering
• Experience with pooled screening and NGS-based readouts, including library preparation and sequencing QC
• Experience with high throughput antibody display technologies, including yeast, phage or mammalian display, is a plus
• Familiarity with single-cell genomics workflows (e.g., scRNA-seq, barcoded or multiplexed assays) is a plus
• Strong analytical skills and the ability to troubleshoot complex experimental issues independently.
• Strong data analysis capabilities, including proficiency with visualization and statistical software (e.g., GraphPad Prism, R, Python).
• Excellent written and verbal communication skills; ability to present scientific findings clearly and concisely to diverse audiences.
• Enthusiastic team player who can work effectively across interdisciplinary teams and drive cross-functional projects.

Compensation

Annual

We offer a competitive compensation and benefits package, seeking to provide an open, flexible, and friendly work environment to empower employees and provide them with a platform to develop their long-term careers. A Summary of Benefits is available for all applicants. We offer a competitive package that includes base salary, bonus, and equity. The base pay range for this position is expected to be $124,000 to $155,000 annually; however, the base pay offered may vary depending on the market, job-related knowledge, skills and capabilities, and experience.