Principal Scientist, Medicinal Chemistry
Join Iambic Therapeutics as a Principal Scientist in Medicinal Chemistry to drive drug discovery in a collaborative environment.
Posted by employer 2 days ago
First seen on Joblaze 1 day ago
Last verified on the company career page 1 day ago
What you'll build
- Devise strategies to identify lead molecules
- Execute on high quality ideas using modern organic chemistry transformations
- Work closely with molecular and cellular biology and pharmacology
- Influence the use of computational methods
- Communicate project updates to the broader team
Must have
- PhD in chemistry with a focus on synthetic organic chemistry
- 8+ years of experience in small molecule drug discovery
- Proven track record of success in advancing programs
- Extensive experience in lead compound optimization
- Expert in modern synthetic organic chemistry approaches
- Experience working with computational chemists
AI in the day-to-day
Work closely with AI/ML teams to develop and implement relevant predictive models to aid in the design of new molecules.
Requirements
- Experience
- 8–15 years
- Education
- PhD
Not disclosed in this posting: compensation, visa sponsorship.
Benefits
Joblaze summary
The Principal Scientist in Medicinal Chemistry at Iambic Therapeutics focuses on developing and optimizing lead molecules for drug discovery, employing advanced synthetic methods and collaborative strategies. This role requires expertise in synthetic organic chemistry and a strong background in small molecule drug development, ideally suited for candidates with significant industry experience. The position emphasizes teamwork across various scientific disciplines, particularly with AI and computational chemistry teams, within a company that values innovation and diversity.
Joblaze insights
- Listed yesterday — first seen on Joblaze October 7, 2026. Last confirmed on Iambic Therapeutics's careers page October 7, 2026.
- This exact title is also open at 1 other location at Iambic Therapeutics: San Diego HQ.
Quick facts
- Is the Principal Scientist, Medicinal Chemistry role remote?
- No — this is an on-site role in San Diego, United States.
- How much experience is required?
- 8–15 years of relevant experience for this Principal Scientist, Medicinal Chemistry role.
- Where is the role based?
- Iambic Therapeutics is hiring for this position in San Diego, United States.
- What seniority level is this role?
- Iambic Therapeutics targets principal-level candidates for this position.
- Is this full-time or contract?
- Full-time for this Principal Scientist, Medicinal Chemistry role at Iambic Therapeutics.
From the original posting
JOB SUMMARY
We seek an experienced and creative medicinal chemist with a proven track record of success in drug discovery. Candidates should be motivated to work in an intensely collaborative, multidisciplinary, team-based setting. The ideal candidate will be passionate about solving medicinal chemistry challenges, as well as proactively interfacing with diverse teams working on automated experimentation, AI-driven molecular generation, property predictions, and bioassay data generation.
This position is on-site at our San Diego Headquarters.
KEY RESPONSIBILITIES
Devise strategies to identify lead molecules and optimize them for potency, selectivity, and ADME properties using multivariant SAR analysis and hypothesis driven design principles.
Execute on high quality ideas by employing a broad range of modern organic chemistry transformations, synthetic methods, creative use of parallel experimentations and implementing innovative techniques.
Work closely with molecular and cellular biology, pharmacology, computational chemistry, ADME, and other key functions
Influence the prospective use of computational methods and leverage automated synthesis and high-throughput experimentation capabilities
Work closely with AI/ML teams to develop and implement relevant predictive models to aid in the design of new molecules
Communicate project updates clearly and effectively to the broader team and key stakeholders
Work as a member of the Chemistry research group and foster a culture of scientific excellence, innovation, and teamwork
QUALIFICATIONS
BS, MS, or PhD in chemistry with a focus on synthetic organic chemistry
Experience in small molecule drug discovery in a biotechnology or pharmaceutical setting and a B.S. with 15+ years’ experience, M.S. with 12+ years’ experience or Ph.D. with 8+ years’ experience.
Proven track record of success in advancing programs from leads to advanced candidates.
Extensive experience in lead compound optimization for potency, selectivity, ADME and PK.
Expert in modern synthetic organic chemistry approaches and principles demonstrated through publications in journals and patents
Ability to integrate multiple R&D disciplines into a successful strategic project plan
Experience working with computational chemists as part of project team in design of drug targets is required
Strong interpersonal, communication, time management, and leadership skills
Creative problem solving and management of relationships with several stakeholders within and beyond the company
ABOUT IAMBIC THERAPEUTICS
MISSION & CORE VALUES
PAY AND BENEFITS
Standard company text repeated across Iambic Therapeutics's postings is omitted here.